My friend Sé Reed has a love/hate relationship with WordPress Frameworks. We’ve discussed this on WPwatercooler a few times now and each time “it depends” comes up as the answer to questions like this.
Leveraging a framework when building out a site makes a stronger foundation (bonus points if your use Foundation framework) since the framework is being used by more than just you. The community at large is using the framework and more items and features are being added to it. This is where my friend Sé sees it as a disadvantage because you are now having to learn a framework instead of using vanilla WordPress thus having to learn and maintain knowledge on two platforms that are ever changing.